Corporate Philosophy
The Otsuka Pharmaceutical Group originated in 1921, with the establishment of Otsuka Pharmaceutical Factory. In the early days, the company was engaged in the manufacture and sale of industrial and pharmaceutical chemicals, and entered into intravenous solutions business in 1946.
In 2008 Otsuka Holdings took over all Otsuka subsidiary companies under it’s control. Today there are 153 companies under the banner of Otsuka Holdings. Today, we “Otsuka Chemical India Ltd” is one of the group company of Otsuka Holdings.
Our first step towards development of this Key technology for the manufacture of GCLE was laid between 1980 to 1982. We started with electrochemical en e-type chlorination of the N-substitute (3-methyl-3-butenoate) of the azetidinones, followed by construction of the cephem framework by ammonia-promoted recyclization. The phenylsulfonyl moiety worked effectively for trapping the in situ generated sufenic acid in the first step, as a protecting group in the en e-type chlorination, and as a good leaving group in the final recyclization step.
We continued our efforts and made improvements in each of the sequential processes up to a level, feasible for industrial production of GCLE
In 1984 we constructed lab scale plant in Japan and started production GCLH and GCLE. In 1988, we succeeded in producing 18mt GCLE in a year. We decided to produce GCLE as our original product and established first commercial plant in 1990 with an installed capacity of 150 mt / year.
Today, Our Japanese plant is producing more than 220 mt GCLE / year. Our efforts to improve GCLE manufacturing technology is continuing even today. Over a period of years, our customer base has also expanded not only in Japan but also in Italy, USA, China, Korea and India.
Finally, we have decided to establish a second plant, our first in India, in 2006. This State of the art, fully automatic plant started producing GCLE in 2008, and today Otsuka Chemical group is the largest producer of GCLE in the world.

Environmental Clearance for Expansion

EC Compliance API Apr-21to Sep-21

EC Compliance GCLE Apr-21to Sep-21

EC Compliance CDTR-Pi Apr-21to Sep-21
Copyright 2009, Otsuka Chemical (India) Private Limited.